Brest Cancer
To
date, most inherited cases of breast cancer have been associated
with two genes: BRCA1, which stands for BReast CAncer gene
one, and BRCA2, or BReast CAncer gene two. Get more information
about genetic abnormities and breast cancer.
The
function of these genes is to keep breast cells growing
normally and to prevent any cancer cell growth. But when
these genes contain abnormalities, or mutations, they are
associated with an increased breast cancer risk. Abnormal
BRCA1 and BRCA2 genes may account for up to 10% of all breast
cancers.
Women
diagnosed with breast cancer who have an abnormal BRCA1
or BRCA2 gene often have a family history of breast cancer,
ovarian cancer, or both. But it's also important to remember
that most women with breast cancer have no family history
of the disease.
Identifying
BRCA1 and BRCA2 has led to new techniques for lowering detecting
and treating breast cancer and lowering the risk for the
disease. For women who wish to be tested, we can now establish
whether the two genes are normal or not.
But
there's still a lot more to learn about these genes. And
other genes probably also play a role in the development
of breast cancer, for women both with and without a family
history of the disease.
The
medical experts for Breast Cancer and Genetics are:
* Rachael Brandt, M.S., C.G.C., genetic counselor, Main
Line Health Cancer Center, Philadelphia, PA
* Generosa Grana, M.D., F.A.C.P., breast cancer genetics
specialist, Cooper Hospital/University Medical Center, Camden,
NJ
* Marisa C. Weiss, M.D., breast radiation oncologist, Lankenau
Hospital, Thomas Jefferson University Health System, Philadelphia,
PA
These
experts are members of the breastcancer.org Professional
Advisory Board, including more than 60 medical experts in
breast cancer-related fields.
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The information on this page has been extracted from http://www.breastcancer.org/genetics_breast_cancer.html.
